PubMed systematic review on BPC-157 in orthopaedic sports medicine
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Patients initiating GLP-1 RA treatment (semaglutide, liraglutide, tirzepatide) were propensity scorematched (1:1) with RA controls not receiving GLP-1 RA therapy, balancing demographics, BMI categories, cardiovascular comorbidities, immunosuppressive therapies, and cardiometabolic medications
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Studies examining ovariectomized, hormone-primed female rats showed: Dramatic increases in solicitation behaviors (hopping, darting, ear-wiggling) at doses of 100-200 mcg/kg No effects on consummatory behaviors such as lordosis Selective enhancement of proceptive (desire-related) behaviors without affecting receptivity Effects mediated through the medial preoptic area, as direct mPOA injections replicated systemic effects These findings established PT-141 as the first pharmacological agent demonstrating selective appetitive sexual behavior enhancement in preclinical models
