Safety Profiles and Adverse Effects Common Adverse Reactions Therapeutic peptides generally exhibit favorable safety profiles compared to many small molecule drugs
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Additionally, catalpol activates the Osteopontin/phosphorylation-insulin-like growth factor 1 receptor (p-IGFR)/mTOR signaling axis, promoting the vitality, migration, and axonal growth of SH-SY5Y cells following OGD/reoxygenation injury, contributing to neuronal protection, nerve cell migration, and axonal regeneration under ischemic and hypoxic conditions ( Catalpol effectively alleviates cognitive impairment and neuropathological damage in isoflurane-exposed aged mice, showcasing its neuroprotective effects (Shi et al., 2022)
Necrosis caused by murine norovirus