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In clinical trials of Wegovy, participants lost an average of 15% of their body weight and more than half lost more

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Pharmacologic therapy of diabetes and overall cancer risk and mortality: a meta-analysis of 265 studies

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One such meta-analysis reported an absolute weight reduction difference of approximately 4.5 kg in favor of retatrutide over tirzepatide

Research indicates potential beta-cell protective effects through reduced glucotoxicity and lipotoxicity, with some evidence suggesting improved beta-cell function over time