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333 AG-270 is an oral selective MAT2A inhibitor that selectively inhibits the proliferation of MTAP null cells and effectively reduces the level of SAM in tumor cells in tissue and xenograft tumor models

In fact, its known as the master antioxidant because it plays such a huge role in keeping other antioxidants in check by neutralizing free radicals

Finicle et al., 2019)

Administration of the Gln synthetase inhibitor CB-839 promotes the differentiation and cytokine secretion of CD4 + Th 1 cells as well as CD8 + T cells while inhibiting the differentiation and co-function of Th 17 cells

Decreased GSH and accumulated ROS levels lead to lipid peroxidation and ferroptosis-mediated tumor suppression

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate