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Notably, chemical chaperones (4-PBA, TUDCA) enhance Gq signaling without reversing this switch, while ER stress-associated UPR factors XBP1 and ATF6 selectively amplify Gs signaling
doi:10.1016/j.gene.2022.146663 Langan RC, Goodbred AJ
These benefits were further supported by the results of the SUMMIT trial, which investigated tirzepatide, a dual GLP-1/glucose-dependent insulinotropic polypeptide receptor agonist, in patients with HFpEF with or without T2D
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