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PKF275-055, an analogue of vildagliptin and a DPP-4 inhibitor, counteracted changes in Na/K-ATPase activity, nerve conduction velocity, and nociceptive thresholds in diabetic rats [50]

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Furthermore, a meta-analysis of multiple studies confirmed that ALA, when combined with other therapies, such as epalrestat, exhibited superior efficacy in improving nerve conduction velocities and reducing neuropathic pain (Zhao et al., 2018)

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