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The main biochemical pathways of acetaminophen metabolism and the transports between various compartments are pictured in the figure below

Ferroptosis is an iron-dependent and programmed cell death mode, which is different from the traditional apoptosis, cell necrosis, or pyroptosis 35

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Notably, the specific composition of membrane phospholipids, particularly the levels of phosphatidylethanolamine (PE) containing polyunsaturated fatty acids (PE-PUFAs), plays a crucial role in determining ferroptosis sensitivity (Kagan et al., 2017)