As little as 3 percent weight loss can have a meaningful benefit for diabetes, hyperglycemia and dyslipidemia (abnormal lipid levels in the bloodstream, which poses a higher risk for cardiovascular disease)but these conditions, along with many others, often require a greater amount of weight loss to lead to health improvements
"Best" becomes meaningful only when qualified by regulatory preferences, financial circumstances, and individual priorities
2018 Sep;20(9):2255-63
Some people lose 20% or more
Wang X, Yu S, Hu JP et al (2014) Streptozotocin-induced diabetes increases amyloid plaque deposition in AD transgenic mice through modulating AGEs/RAGE/NF-B pathway
Among injectable options, liraglutide is less expensive than other GLP-1 medications, as a generic version is available