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Metformin improves insulin sensitivity, reduces hepatic glucose production, and may have longevity benefits

Because of this dual action, tirzepatide often provides stronger appetite control, improved metabolic effects, and larger average weight-loss outcomes for many patients

Matt Kaeberlein (UW Medicine, Optispan) observed: Expecting a single drug to meaningfully alter the course of Alzheimers once cognitive decline is underway is an extraordinarily high bar. The EVOKE population already had MCI or mild dementiameaning pathological cascades were well-established

PMID: 27 PeterME

doi: 10.1038/nrn3819 54 KheraR.MehanS.BhallaS.KumarS.AlshammariA.AlharbiM.et al

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