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This guide gives you the head-to-head breakdown: mechanisms, evidence, dosing, when to choose each, and how to combine them for maximum effect

Acknowledgements We thank the team of OpenGWAS and UK Biobank database for making the summary data publicly available, and we would like to acknowledge the principal investigators of the studies who made their data openly accessible for research

Semaglutide + Tirzepatide : These should NOT be combined simultaneously as they act on overlapping pathways

Amino acids, 51(2), 193204

About the authors Maggie Evans is a certified diabetes educator and registered dietitian nutritionist