prausnitzii is reported to be lower in patients with NASH/MASLD in several cohorts, and preclinical plus clinical interventions that increase butyrate production for example dietary fermentable fibers (inulin, fructo-oligosaccharides) or targeted probiotic/next-generation probiotic approaches can raise Faecalibacterium or butyrate levels and improve markers of hepatic steatosis and systemic inflammation (87, 88)
Zepbound (tirzepatide for obesity) uses the same schedule as Mounjaro: escalating from 2.5 mg up to 15 mg/week in 4-week steps
Vegetarians and vegans may have lower dietary intake but generally maintain adequate levels through endogenous synthesis
Lillys triple agonist, retatrutide, demonstrated significant reductions in A1C and weight in first Phase 3 trial for treatment of type 2 diabetes (TRANSCEND-T2D-1)
As far as sarms go, i have mixed feelings about them
It stimulates the pancreas to release insulin more effectively when blood glucose levels are high while also reducing the livers production of glucose