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Metabolites of the Microbiota in GLP-1RA Inflammation and Gut Microbiome The significance of GLP-1 in the mitigation of inflammation is underscored because enteroendocrine cells (EECs) discharge GLP-1 not only as a result of the nutrient influx but also due to stimuli like interleukin-6, microbial by-products, lipid amides, and proteins, lipopolysaccharides (LPSs), and gut injury from ischemia [20]

Key Takeaway: Leg pain while taking semaglutide is usually a secondary effect of lifestyle changesspecifically changes in hydration, mineral intake, and the rate of weight lossrather than a direct toxic effect of the medication on muscle tissue