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The first-line nod was given based on data from the Phase III KEYNOTE-859 study, where the Keytruda-based regimen cut the risk of death by 22% versus chemotherapy alone

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In patients with active RA, the addition of low-dose sirolimus (0.5 mg every other day for 24 weeks) to conventional immunosuppressive therapy effectively increased Treg cell frequencies, reduced Th17 cell populations, and improved clinical disease activity (Chictr.org.cn identifier: ChiCTR-IPR-17010307) (240)

Reported side effects in human anecdotal use are rare and mild, typically limited to injection site irritation or transient headaches

p38 MAPK regulates Th2 cytokines release in PBMCs in allergic rhinitis rats