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No controlled trial comparing intra-articular AOD-9604 to placebo or standard intra-articular therapies (hyaluronic acid, corticosteroids) has been completed

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Modulation of TLR pathways, through agonists to boost antimicrobial defense or antagonists to dampen excessive inflammation, has emerged as a therapeutic strategy

But if it does get approved, retatrutide is being studied as a weekly subcutaneous injection

doi: 10.3389/fimmu.2018.01154 119 PetrocheilouAMoudakiAKaditisAG

Future research should prioritize well-designed, equally powered clinical trials to validate the efficacy and safety of these plant-based interventions