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When these cells detect the presence of nutrients from the food weve eaten, they release GLP-1

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And because these medications need to be taken consistently over many years, the costs incurred may surpass that of metabolic surgery after less than a year

Luo et al

Following discontinuation, most patients (56%-60%) restarted their index therapy

Using doses below the therapeutic threshold may provide insufficient metabolic benefit, essentially exposing patients to medication risks without meaningful clinical gain