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Persistent nausea and vomiting : Especially if unable to keep down fluids, raising dehydration concerns

While early open-label and phase 2 trials suggested potential benefits of arbaclofen in children with ASD, subsequent phase 3 randomized controlled trials failed to demonstrate significant efficacy over placebo on primary outcomes, despite favorable safety and tolerability profiles

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Research shows they're also under-consuming fiber, calcium, iron, and magnesium

More research is needed to understand this fully