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Epileptogenesis is defined as the latent period between the initial brain insult and the first unprovoked seizure, where very intensive neuronal alterations take place, including oxidative stress, the expression of pro-inflammatory mediators, neurodegeneration, reactive gliosis, damage to the blood-brain barrier, increased epileptiform spiking, and spontaneous recurrent seizures (Borowicz-Reutt and Czuczwar 2020)

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