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While it has been studied over one to two years in clinical trials, there is limited data beyond that time frame, especially regarding: Long-term metabolic effects Nutrient deficiencies due to reduced food intake Potential changes to gut microbiota Dependency on the drug to maintain weight loss Potential changes to gut microbiota Some clinicians have voiced concern that stopping Ozempic can result in rapid weight regain and the return of previous metabolic issues

Clinical Update 1/18/2014 Green Tea "Blocks" Beta-Blocker A new study shows that drinking green tea can drastically reduce the amount of a beta-blocker (nadolol, Corgard) absorbed into the bloodstream

Metformin may also cause digestive symptoms, so some patients experience overlapping GI effects during the first 24 weeks of combination therapy

The most common side effects are gastrointestinal: nausea, vomiting, diarrhoea, constipation

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