[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Tuttle KR
In turn, this has sparked changes in the ways in which traditional PBMs price and reimburse prescription drugs for their clients
However, their overactivation can lead to neurodegenerative diseases such as AD, PD, Huntington's, and amyotrophic lateral sclerosis (Wu and Zhuo 2009)
Some observational data suggested increased risks in certain populations (e.g., 98% higher risk of any psychiatric disorder in one 2024 cohort), while others, including analyses of STEP trials and large registries, found no increased risk or even small reductions in depressive symptoms compared to placebo or other antidiabetics
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