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The deficiency of phosphatase and tensin homolog (PTEN) hyperactivates the mTOR pathway, which contributes to altered social interaction and the development of macrocephaly [197]

The wide-ranging binding properties were similar to those of albumin in blood plasma and the name ligandin was therefore coined ( A completely different binding function was uncovered when GST of the pi class was found to be an endogenous inhibitor of Jun N-terminal kinase (JNK), thereby contributing to regulation of a protein kinase responsive to cellular stress ( In addition to the dimeric cytosolic GSTs, which are in focus in the present article, trimeric membrane-associated GST proteins, have also been identified

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