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Jensen DM, Korsholm L, Ovesen P, Beck-Nielsen H, Moelsted-Pedersen L, Westergaard JG et al (2009) Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes

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In addition to these mild adverse events, it is likely that loss-of-function BHMT polymorphisms may also pose a challenge in conducting human trials