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Circulating ghrelin levels are decreased in human obesity

While GLP-1 receptor agonists improve insulin sensitivity via the Cyclic Adenosine Monophosphate (cAMP)/cAMP-dependent Protein Kinase (PKA) pathway, they may not fully suppress intrahepatic inflammatory axes such as TNF-/IL-6-JAK/STAT3 56,57

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The dosage and duration of therapy depend on the individuals medical condition, laboratory findings, and treatment response