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The mechanism involves clearance of senescent Leydig cells that secrete pro-inflammatory SASP factors (IL-1, IL-6, TGF-) which impair testosterone production in neighboring healthy cells
In hamsters, the NO donor S-nitroso-L-glutathione stimulated, while NOS inhibitor attenuated, the release of stored TGs during post-absorptive stage ( An additional mechanism for GLP-2 to release intestinal lipid stores may involve the modulation of lymphatic functions
Individuals with pre-diabetes , Type 1 or Type 2 diabetes , or metabolic syndrome should avoid IGF-1 peptides unless under direct medical supervision.
For patients with severe obesity-related complications, providers may lean toward therapies with the strongest efficacy data currently available
