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These studies argue that there must be sex differences as women have reported to present rapid cycling more often than men, besides the onset in female patients occurs with depressive phases and present more mixed manic presentations Moreover, BD can be accompanied by psychiatric comorbidities such as anxiety or substance abuse and impulse control disorders [13]

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Higher log-transformed levels of TMAO were associated with lower TICS scores over time in the adjusted linear mixed model ( = -1.2, 95%CI -3.25to-0.12

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A study of rats exposed chronically to OTA, even at doses that resulted in 25% of the animals developing kidney tumor formation, the gene expression profile showed down-regulation of the antioxidant genes [73]