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NF-kappa B signaling: multiple angles to target OA

NCOA4 inhibitors have been explored as potential therapeutic agents to prevent excessive ferritin degradation, thereby reducing intracellular free iron levels and minimizing the risk of ferroptosis (78,79)

Nature Reviews Drug Discovery , v

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Moreover, KPV has been investigated in preclinical models for potential anti-inflammatory effects, primarily through inhibition of intracellular NF-B and MAP kinase signaling pathways, independent of melanocortin receptor mechanisms