There is also a study by La Roche Posay (belongs to L'Oreal) that examined the anti-aging effects of 5% Vitamin C combined with 0.1% Madecassoside
Am J Neurosci 3(1):1724 Thirupurasundari CJ, Padmini R, Devaraj SN (2009) Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats
Although important in many reactions in bacteria, its metabolic role in higher animals, including humans, remains unclear
Rare serious adverse events: pancreatitis, gallbladder disease, acute kidney injury
One case report states that the recovery of the products of oxidative metabolism in a child was 12% following overdose compared to an expected rate of 3543% reported in adults
This is the most straightforward measure and the one most clinical trials report