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Description

The bioavailability of GLP-1 RAs administered orally alone is very low and, in order to avoid degradation, the active molecule has to be protected and delivered through the GI epithelium and into the bloodstream

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Roughly 85% to 90% of a therapeutic dose undergoes Phase II conjugation (glucuronidation via UGT1A1, UGT1A6, and UGT1A9, plus sulfation via SULT1A1), with only about 5% to 10% oxidized by CYP2E1 into the reactive metabolite NAPQI, per Hodgman and Garrard's pharmacology review

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