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The electrons accepted during these reactions help form ATP in eukaryotes through the electron transport chain

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Immunoblotting revealed that EPAS1 knockdown resulted in more than a 3.5-fold increase in HIF-1 protein expression under hypoxia, leading to upregulation of downstream mitophagy-related proteins BNIP3 and NIX in M9a+sh EPAS1 cells (Fig

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