There are several possible reasons why you aren't losing more weight on semaglutide, including too low of a dose, individual response, poor diet, lack of exercise, having been on long enough, using drugs or alcohol, not taking your dose at the proper time, or not drinking enough water
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IC50 was calculated according to cell viability using the nonlinear regression analyses in GraphPad Prism 10.0 software
As a dual agonist targeting GLP-1 and GIP receptors, Tirzepatide demonstrates that adding receptor activity does not necessarily worsen side effects
Some achieve their weight loss targets in 8 weeks at 12mg
However, seeking professional supervision before increasing the dose is important as it may lead to increased side effects