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Sayed-Ahmad et al., 2022)

Funding This review received no external funding or grants from any agency or organization

Seek emergency medical evaluation the same day if you experience severe, persistent upper abdominal pain, especially if accompanied by vomiting, fever, or pain radiating to your back

Lancet 390 , 24812489 (2017)

10.1002/(SICI)1099-1492(199712)10:8 3.0.CO;2-0 47

Compulsive use, marked by an inability to abstain or limit intake in spite of awareness of harmful outcomes, is a defining characteristic of substance use disorders (SUDs) (Health et al., 1988