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doi: 10.1016/j.freeradbiomed.2024.11.021 42 EltokhyAKEl-ShaerRAAEl-DeebOSFarghalEEIbrahimRRElesawyRet al
In this pooled analysis of patients with heart failure and preserved ejection fraction across the SELECT, FLOW, STEP-HFpEF and STEP-HFpEF diabetes trials, semaglutide significantly reduced the risk of cardiovascular death or worsening heart failure as compared with placebo, as well as worsening heart failure events alone, but the effects on cardiovascular death were not significant, Mikhail Kosiborod, MD, FACC, FAHA, cardiologist at Saint Lukes Mid America Heart Institute and professor of medicine at the University of Missouri-Kansas City School of Medicine, said during a presentation
The approaches are mechanistically contradictory exogenous HGH suppresses pituitary GH production, which would blunt the secretagogues' mechanism of action
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