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This event increases the amount of 5,10-methyleneTHF available to be channelled into de novo thymidylate synthesis

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Galasso, C., Orefice, I., Pellone, P., Cirino, P., Miele, R., Ianora, A., Brunet, C., & Sansone, C

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Methotrexate suppresses the function of folate by reducing the intracellular synthesis of tetrahydrofolates from dihydrofolates

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