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In response to extrinsic stimuli, inositol 1,4,5-trisphosphate (IP 3 ) and ryanodine receptors release Ca 2+ from the ER to the cytosol, whereas the sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) pumps Ca 2+ against the gradient to maintain a concentration difference between the ER lumen and the cytosol at rest

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