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By integrating evidence across organ systems, we aim to provide a theoretical framework for understanding dairy cow health as an emergent property of the holobiontoffering a novel perspective for precision livestock management

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It activates the SIRT1/peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) pathway to promote mitochondrial biogenesis, regulate mitochondrial homeostasis, and inhibit the high mobility group protein (HMGB)1/TLR4/p38/extracellular regulated protein kinases (ERK)1/2 pathway to reduce inflammatory responses in CIA mice (259)

Decreased very long chain polyunsaturated fatty acids in sperm correlates with sperm quantity and quality