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We employed MR-Egger regression, weighted median, and modebased estimators (including both weighted and simple mode) to obtain robust causal effect estimates even if a subset of the instruments were invalid

Therapeutic strategies that directly reduce mortality and extend healthspan are therefore urgently needed

GLP-1 receptor expression in intima and media was lower in obesity group compared to non-obesity group which was correlated with the alteration of TCF7L2 expression

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In addition, our results help validate the recently developed techniques of DMRS and whole-brain functional connectivity as preclinical in vivo methods with good correspondence to existing PET methods