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Clinical Context from Trials Pivotal trials showed low pancreatitis rates: STEP trials (semaglutide) had 0.1-0.2% events vs

Tirzepatide (Zepbound, Monjaro) A dual-hormone (GLP-1/GIP) medication designed to reduce hunger and support meaningful weight loss under medical guidance

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KEY POINTS TO REMEMBER Liver enzyme (ALT) activity should be measured prior to initiation of therapy (it may be considered during dose titration) and no routine monitoring is necessary during treatment continuation (unless clinical symptoms develop)

Making sure that we're getting enough B vitamins like folate that can help this process of our bodies creating glutathione, Epsom salt baths, and other lifestyle changes that can help us improve our body's nutritional state

Additional research is required to ascertain the variability in the risk of biliary diseases associated with GLP-1 RAs