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In pancreatic function, it serves as a crucial incretin hormone, increasing insulin production in response to oral glucose consumption as opposed to intravenous delivery

Recent Developments: Developed HM15275, a tri-agonist targeting GLP-1, GIP, and glucagon receptors, showing potential for significant weight loss and improved metabolic health

It is also indicated for weight management when used alongside a reduced-calorie diet and increased physical activity

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While its a very small volume, for protocols requiring extreme precision with micro-doses, some researchers account for this or use special low-dead-space syringes to minimize it

Figure 1 describes the mechanism of action of semaglutide and tirzepatide and their way of promoting weight loss and improving glycemic control