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Description

The siRNA target sequences are listed in Supplementary Table 2

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Only subjects exposed for 24 h per day to dichlorvos concentrations above 0.1 mg/m 3 or patients with liver insufficiency showed even a moderate decrease in plasma ChE activity (Cavagna et al., 1969, 1970

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Wedzicha JA, Calverley PMA, Rabe KF

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Medication adjustments may be considered in consultation with prescribing clinicians: Dose reduction : Lowering the Ozempic dose may reduce symptom severity whilst maintaining some glycaemic benefit Slower titration : Increasing the dose more gradually than standard protocols may improve tolerability Prokinetic agents : In the UK, medications such as metoclopramide are generally restricted to short-term use (maximum 5 days) due to neurological side effect risks

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