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The accumulation of glial cells in the outer retina and choroid further exacerbates inflammation by releasing cytokines, impairing fluid clearance, and contributing to the development of DME [81]

However, this threshold assumes normal glutathione stores and hepatic function

Individuals carrying significant excess weight often experience faster initial loss because their calorie deficiteven with modest portion reductionexceeds their energy expenditure by a larger margin

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This can look like a temporary worsening of acne