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Weight loss injections, particularly glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide (Wegovy for weight management, Ozempic for type 2 diabetes) and tirzepatide (a dual GIP/GLP-1 receptor agonist marketed as Zepbound for weight management and Mounjaro for type 2 diabetes), have become increasingly prescribed medications

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Stop or switch in consultation with your prescriber if any of the following appear despite hitting the 7 rules above: hand-grip strength drops more than 10% from baseline, you cannot climb one flight of stairs without significant fatigue, a 6-month DEXA shows more than 25% of total weight loss as lean mass, or you are losing more than 1.5% of bodyweight per week despite eating 1.6 g of protein per kilogram

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