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Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): A multicentre, open-label, randomised, phase 3a trial

2023;9:e20534

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Relevant in vivo and in vitro experiments have confirmed that IGFBP-L1 methylation exerts a pro-oncogenic effect by promoting PI3K/AKT phosphorylation and IGFBP-L1 methylation has become a potential marker for the early detection of esophageal cancer, as well as a predictive marker for PI3K-targeted therapy in esophageal cancer (85)

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