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These conditions result in low IGF-I concentrations, and changes in IGF-I positively correlate with changes in lean body mass[369, 370], as well as reversal of acute catabolic states is associated with an increase in IGF-I levels[371, 372]

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Tirzepatide reduces appetite through GIP and GLP-1 receptor activation in appetite-regulating brain centers, working through physiologic satiety pathways