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doi: 10.1074/jbc.RA118.007222 15 Bagua TorresJ.YuZ.BordoloiJ.SunasseeK.SmithD.SmithC.et al

In addition, it has now been demonstrated to have beneficial effects on musculoskeletal soft tissue injuries and gastrointestinal tract lesions or lesions in the liver, two non-healing wounds that significantly impact health and disease

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Specifically, researchers use this compound to explore how it may influence central nervous system activity and cellular communication in controlled laboratory environments

Several research groups have attempted to delineate the underlying mechanisms of irAEs, as curated by the authors of the Cancer Immunology Research paper below