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Experimental approachescell culture A549 cells (human alveolar basal epithelial adenocarcinoma) were maintained at 37 C with 5% CO 2 in RPMI 1640 Medium containing 10% ( v/v ) inactivated fetal calf serum (FCS) and 100 g/mL penicillin-streptomycin

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DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request

& Ganapathy, V