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The legal access landscape shifted meaningfully in April 2026 when the FDA removed both peptides from its Category 2 restricted list
44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops
This supports the mitochondria during the high-demand healing phase [1, 3]
The good news is that vitamin B12 deficiency is common and usually straightforward to manage with appropriate medical support
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