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GIP, or glucose-dependent insulinotropic polypeptide, is another incretin hormone that stimulates insulin secretion

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A proper diet and adequate sunlight may help maintain vitamin levels in the long term, but supplementation is often necessary

Additionally, islets isolated from individuals with type 2 diabetes exhibit decreased DPP-4 activity in order to preserve GLP-1 secretion in culture, further implicating a functional role of endogenous islet GLP-1 in diabetes [29]