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Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects

Shes interim co-director of the Roanoke, Virginia-based Fralin Biomedical Research Institute at VTCs Center for Health Behaviors Research

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The oxidation of NADPH to NADP+ is accompanied by a decrease in absorbance at 340 nm

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Specifically, uncontrolled elevated intracellular lactate concentrations disrupt the NADH/NAD+ ratio, thereby impairing the activity of key glycolytic enzymes, particularly GAPDH due to NAD+ depletion (50,57)