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Future research should focus on improving the efficiency of genetic engineering, overcoming the challenges posed by anaerobic characteristics and spore germination, minimizing the metabolic burden on host bacteria, reducing immunogenicity, and enhancing colonization efficiency

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Abbott Laboratories)

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Whereas sample sizes for studies included in the review were larger (Ghrelin: M(N)=23, Med(N)=27

Reported adverse events are generally mild and local, such as transient injection-site redness, itching, or bruising