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Microglia biology: one century of evolving concepts

3.2 Proteomics and targeted validation identify sphingolipid metabolism as a key pathway modulated by SE To uncover the molecular mechanisms underlying SEs neuroprotective effects, we first conducted an exploratory proteomic analysis of the cerebral cortex

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Mechanistically, resmetirom enhances hepatic lipid oxidation, rapidly reduces liver fat content, and modulates intrahepatic metabolic and fibrogenic pathways, with relatively modest effects on body weight [20,21]

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The research community is watching the TRIUMPH Phase 3 program closely