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Therefore, reduction or deletion of ZIP14 negatively affects adipose function, impairs late adipocyte differentiation, and promotes the acquisition of a hypertrophic phenotype often associated with insulin resistance

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(2023) reported that dapagliflozin (1 mg/kg/day administered intragastrically for 6 weeks) alleviated diabetes-induced depressive-like behaviors in rats, a model generated through high-fat diet feeding followed by low-dose streptozotocin administration

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However, several indirect mechanisms warrant consideration